Colloidal Gold Nanoparticles: A Versatile Platform for Developing Tumor Targeted Cancer Therapies
نویسندگان
چکیده
CytImmune Sciences, Inc. 9640 Medical Center Drive, Rockville, MD, 20850: email: [email protected] Virginia Polytechnic Institute and State University, Department of Chemistry Blacksburg, VA 24061 Colloidal gold nanoparticles represent a versatile biomedical platform. Our efforts have focused on the development of these nanoparticles into a platform technology for developing tumor targeted drug delivery vectors. In the current communication, we describe the development of two colloidal gold nanoparticle drugs. The first drug, Aurimune-T, is a multivalent drug assembled on 25 nm colloidal gold nanoparticles and designed to sequester TNF in solid tumors. While developing Aurimune-T we recognized that TNF not only serves as the therapeutic responsible for anti-tumor efficacy but also a tumor targeting ligand. Support for this hypothesis is presented in the description of the second nanoparticle drug, AuriTax, a colloidal gold-based TNF targeted paclitaxel drug.
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